Modeling of articular cartilage growth around localized defect-filling metal implant

Authors: Manda, K., Eriksson, 
Document Type: Article
Pubstate: Submitted
Journal: Journal of Biomechanical Engineering
Year: 2013


The long term objective of the present work is to develop a finite element model of an articular cartilage growth around a metal implant, filling full thickness cartilage defects, by including more in vivo dynamic loading situations. A simplified 2D axisymmetric representation of a human femoral condyle articular cartilage was developed. The cartilage was modeled as a biphasic hyperelastic fluid-saturated porous medium by considering two individually growing constituents (proteoglycans and collagens) in the solid matrix of cartilage. A finite element model was developed to simulate the growth of the articular cartilage around the defect edge. Dynamic and spatially varying mechanical loading cases were considered, which we assumed trigger the in vivo growth of the cartilage. We considered two triggering criteria: maximum shear stress and fluid velocity magnitude. We simulated the growth of the cartilage for 90 days. From the simulations, it is proved that the mechanical environment around the metal implant stimulates the growth and remodeling of the cartilage. The sensitivities of the triggering criteria in the physiological range are also reported.